loss product safe weight There has been a recent resurgence in combination therapy clinical development with the development of 3 combinations: Qnexa (topiramate + phentermine), Empatic (bupropion + zonisamide) and Contrave (bupropion + naltrexone).
Future developments
Other classes of drugs in development include lipase inhibitors, similar to orlistat. Another lipase inhibitor, called GT 389-255, is being developed loss product safe weight by Peptimmune (licensed from Genzyme). This is a novel combination of an inhibitor and a polymer designed to bind the undigested triglycerides therefore allowing increased fat excretion without side effects such as oily stools that occur with orlistat. The development seems to be stalled as Phase 1 trials were conducted in 2004 and there has been no further human clinical development since then.
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Wednesday, 15 July 2009
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